Curcumin is a member of the diarylheptanoid class of natural products (curcuminoids) derived from the rhizome of Curcuma longa L., an East Indian plant, commonly called turmeric. Curcumin is the most studied compound in the world. Bruno MD’s curcumin phytosome is independently endorsed by the prestigious Cleveland Clinic as the #1 doctor recommended curcumin formulation in the turmeric market and the formulation of choice for their leading practitioners and their patients. Turmeric and has been used for thousands of years in Southeast Asia, China, and India for cooking and medicinal uses. Curcumin Phytosome is clinically proven in 35 randomized, double-blind, placebo-controlled, published clinical trials to promote a healthy inflammatory response, boost immune response, and provide relief from exercise-related pain. It works through multiple pathways on multiple targets to provide complete relief throughout the body. The extract has been standardized and contains the full bouquet of curcuminoids, not just curcumin (Curcuminoids are polyphenolic pigments and include 77% curcumin, 17% demethoxycurcumin, and 3% bisdemethoxycurcumin). It is called a “Life Guardian” because it helps control chronic inflammation and boost immune response at any age. Western scientists have rigorously tested Turmeric and its compounds for decades, including for heart disease. Results show that Turmeric has several beneficial effects on the cardiovascular system: (vii.193) Prevent or delay the development of atherosclerosis in healthy people. (vii.68) Protect the heart from inflammation and atherosclerosis promoted by chronic exposure to air pollution. (vii.194) Regulate or help lower high blood pressure. (vii.193, 195) Restores antioxidant levels and reduces free radical damage from toxic chemotherapy drugs. (vii.193) Improve age-related stiffening of blood vessels, especially combined with exercise. (vii.196) Reduce heart damage caused by chronic kidney disease (by blocking free radical damage and boosting mitochondrial function). (vii.197) Help stop the formation of dangerous blood clots, including those that cause stroke. (vii.198-199) Prevent cardiac hypertrophy due to high blood pressure, heart attack, high salt intake, or diabetes. An enlarged heart can lead to heart failure and even death. (vii.193) Protects the heart from injury caused by sepsis and chemotherapy drugs. (vii.193, 200) Turmeric’s rhizome contains potent antioxidant and anti-inflammatory compounds. Studies suggest that some of the ways turmeric compounds protect liver cells and can help prevent liver fibrosis are as follows: (vii.13) Stimulating transcription factor proteins that prompt genes to generate natural antioxidants (such as glutathione). (vii.13) Preventing activation and growth of cells in the liver that produce excess structural components. Hepatic stellate cells (HSCs) and fibroblasts are the cells mainly involved in fibrosis. (vii.13) Suppressing inflammatory transcription factors (such as NF-κB) and cytokine proteins (such as TNF-α) that can activate HSCs directly and/or indirectly. For example, TNF-α directly blocks signals from insulin, the hormone needed to metabolize blood sugar. Impaired sugar metabolism can activate HSCs. (vii.13, 31, 279) Promoting other transcription factor proteins, such as PPAR-γ, that block the activation and proliferation of HSCs. PPAR-γ also suppresses the expression of inflammatory proteins, such as the growth factor TGF-β, that promote collagen production. (vii.13, 198) Decreasing harmful triglyceride and cholesterol deposits in the liver. (vii.279) Reducing type I collagen, the primary substance in fibrotic scar tissue in the liver produced by HSCs and fibroblasts. (vii.284)

Indian Frankincense is a botanical extract harvested from the gum resin of the Boswellia Serrata tree. Boswellia Serrata Phytosome helps govern inflammatory response in the joints, bones, respiratory airways, the bowel, and brain. In addition, clinical studies have shown that a cocktail of AKBA (Acetyl-11-Keto-𝛃-Boswellic Acid) and curcumin significantly inhibit certain viral infections (viral entry) compared to the untreated control. BRUNO MD uses Boswellia Phytosome extract that is 400% more bioavailable than regular Boswellia.

The use of Echinacea is traced back to Native Americans who used it as a natural anti-inflammatory. Historically other uses include relief of mouth pain and toothache, treatment of the common cold and cough, tonsillitis relief, and treatment of septic diseases. Bruno MD cultivates our coneflower from an Italian varietal. Our plants guarantee high polysaccharides and low cross-contamination between Echinacea species. Echinacea Angustifolia Phytosome is optimized for maximum absorption. Results in clinical trials conducted using our triple-standardized Echinacea Phytosome have shown a statistically significant tendency to be more efficacious than flu vaccination alone, suggesting that E. Phytosome has the potential to act synergistically with influenza vaccination.

The Bruno MD formulation begins at the cellular base level with a Proprietary Nucleoflam Nucleotide & Nucleotides Yeast Extract Complex. These nucleotides are vital to maintaining essential cell functions and supporting a healthy immune system, digestive system, and brain function. Nucleotides also enhance the anti-inflammatory activity of Vitamin C, Vitamin D3, and Zinc. They are gluten-free, vegan, kosher, and halal. BRUNO MD combines Nucleoflam with Astaxanthin, the most potent anti-inflammatory known in Nature. Together they create a powerful shield against chronic inflammation.

Astaxanthin is the most potent anti-inflammatory known in NatureNature. In addition, natural astaxanthin has clinically demonstrated the ability to balance and strengthen the immune system while enhancing antibody production. This increase in antibodies improves our bodies’ defense against inflammation and the pathogens that can make us sick. Astaxanthin can also help reduce high blood pressure, improve heart health, prevent type II diabetes, and decrease the risk of brain damage from a stroke. Over 95% of commercial astaxanthin is synthetic. Worse, it is harvested using petrochemicals. Bruno MD Astaxanthin is naturally derived from Haematococcus Pluvialis algae, found in temperate environments around the world to produce the highest concentrations of astaxanthin with the highest bioavailability.

Quercetin is a plant-based antioxidant that has proven benefits, including anti-Inflammation properties and the promotion of Immunity. Quercetin is not an easy nutrient to get into your diet. To obtain just one daily dose of quercetin you’d need to eat about 100 kilos of broccoli. Additionally, quercetin is a polyphenol which is rejected by our bodies. Bruno MD uses Phytosome technology to bring the benefits of quercetin to every cell in your body. Research has substantiated that Quercetin Phytosome is 2000% more bioavailable than standard quercetin. Clinical studies confirm that quercetin has strong antiviral and antiinflammatory effects. A natural immunomodulator, quercetin helps block harmful viruses and bacteria and even demonstrates anti-cancer properties. The ultra bioavailability provided by the Phytosome delivery system also improves athletic performance and accelerates fitness recovery with quercetin’s proven anti-inflammatory properties. [43,44] Quercetin’s anti-inflammatory potential can be expressed on different cell types, both in animal and human models [45,46,47,48,49,50,51,52,53]. It possesses both mast cell stabilizing and gastrointestinal cytoprotective activity [54] and can also play a modulating, biphasic, and regulatory action on inflammation and immunity [53]. Additionally, quercetin has an immunosuppressive effect on dendritic cell function [55].