Curcumin is a member of the diarylheptanoid class of natural products (curcuminoids) derived from the rhizome of Curcuma longa L., an East Indian plant, commonly called turmeric. Curcumin is the most studied compound in the world. Bruno MD’s curcumin phytosome is independently endorsed by the prestigious Cleveland Clinic as the #1 doctor recommended curcumin formulation in the turmeric market and the formulation of choice for their leading practitioners and their patients. Turmeric and has been used for thousands of years in Southeast Asia, China, and India for cooking and medicinal uses. Curcumin Phytosome is clinically proven in 35 randomized, double-blind, placebo-controlled, published clinical trials to promote a healthy inflammatory response, boost immune response, and provide relief from exercise-related pain. It works through multiple pathways on multiple targets to provide complete relief throughout the body. The extract has been standardized and contains the full bouquet of curcuminoids, not just curcumin (Curcuminoids are polyphenolic pigments and include 77% curcumin, 17% demethoxycurcumin, and 3% bisdemethoxycurcumin). It is called a “Life Guardian” because it helps control chronic inflammation and boost immune response at any age. Western scientists have rigorously tested Turmeric and its compounds for decades, including for heart disease. Results show that Turmeric has several beneficial effects on the cardiovascular system: (vii.193) Prevent or delay the development of atherosclerosis in healthy people. (vii.68) Protect the heart from inflammation and atherosclerosis promoted by chronic exposure to air pollution. (vii.194) Regulate or help lower high blood pressure. (vii.193, 195) Restores antioxidant levels and reduces free radical damage from toxic chemotherapy drugs. (vii.193) Improve age-related stiffening of blood vessels, especially combined with exercise. (vii.196) Reduce heart damage caused by chronic kidney disease (by blocking free radical damage and boosting mitochondrial function). (vii.197) Help stop the formation of dangerous blood clots, including those that cause stroke. (vii.198-199) Prevent cardiac hypertrophy due to high blood pressure, heart attack, high salt intake, or diabetes. An enlarged heart can lead to heart failure and even death. (vii.193) Protects the heart from injury caused by sepsis and chemotherapy drugs. (vii.193, 200) Turmeric’s rhizome contains potent antioxidant and anti-inflammatory compounds. Studies suggest that some of the ways turmeric compounds protect liver cells and can help prevent liver fibrosis are as follows: (vii.13) Stimulating transcription factor proteins that prompt genes to generate natural antioxidants (such as glutathione). (vii.13) Preventing activation and growth of cells in the liver that produce excess structural components. Hepatic stellate cells (HSCs) and fibroblasts are the cells mainly involved in fibrosis. (vii.13) Suppressing inflammatory transcription factors (such as NF-κB) and cytokine proteins (such as TNF-α) that can activate HSCs directly and/or indirectly. For example, TNF-α directly blocks signals from insulin, the hormone needed to metabolize blood sugar. Impaired sugar metabolism can activate HSCs. (vii.13, 31, 279) Promoting other transcription factor proteins, such as PPAR-γ, that block the activation and proliferation of HSCs. PPAR-γ also suppresses the expression of inflammatory proteins, such as the growth factor TGF-β, that promote collagen production. (vii.13, 198) Decreasing harmful triglyceride and cholesterol deposits in the liver. (vii.279) Reducing type I collagen, the primary substance in fibrotic scar tissue in the liver produced by HSCs and fibroblasts. (vii.284)