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Frequently Asked Questions

Orders

If you want to edit payment method, shipping information or order content, you will need to access your order at www.brunomd.com (top right of the homepage). You will need to create an account if you did not do it at the time of purchase. Please use the same email address that was used when the purchase was made to link the order to the account. If an account has already been created simply log in using your email address and password. You can do this by clicking on the ‘person’ icon located next to the basket icon on the home page (top right-hand corner). You will be redirected to the order history page and on the order line there is an option to ‘cancel/edit’ your order.

If you need further assistance, feel free to contact us via email at customercare@brunopharma.com, or by calling our customer care department at Toll Free # 866-816-3400.

1. If you want to cancel your first order that has not been shipped, follow the instructions below:

• If an account was not created at the time of purchase, then one will need to be created to cancel the order.

• Please use the same email address that was used when the purchase was made to link the order to the account.

• If an account has already been created simply log in using your email address and password. You can do this by clicking on the ‘person’ icon located next to the basket icon on the home page (top right-hand corner). You will be redirected to the order history page and on the order line there is an option to ‘cancel/edit’ your order.

• If you need further assistance, feel free to contact us via email at customercare@brunopharma.com, or by calling our customer care department at Toll Free # 866-816-3400.

2. If you want to cancel your first order that has been shipped, follow the instructions below:

• You will need to create a returns request via our returns center. You can access this by visiting our site www.brunomd.com and navigating to the returns tab located at the bottom of the homepage.

• Click on “Returns” (under the info tab). You will be redirected to the returns center page, and there you will prompted to input your order number and email address to start the process. As there is no need to return the first order, we will refund you in full once we have received your request. Our system will generate our systems will generate an RMA, please ignore it. You will be refunded in full once your request has been processed by our customer care department.

3. If you want to cancel any subsequent orders including subscribe and save orders, follow the instructions below:

• You will need to access your order at www.brunomd.com (top right of the homepage) to handle any rescheduling or cancellation related to any subsequent orders or any subscribe & save orders.

• However, if you are unable to make the necessary changes or require further assistance, please do not hesitate to contact us by email at customercare@brunopharma.com, or call us at 1-866-816-3400 where a member of our support team will be happy to assist you.

4. If you want to return your orders, follow the instructions below:

• There is no need to return your first order. Although our systems will generate an RMA, please ignore it. We offer a full refund for your first order without the hassle of having to return any product. You will be refunded in full once your request has been processed by our customer care department.

• To receive a full refund, all subsequent orders, or all subscribe & save orders must be returned unopened and sealed. We do not issue refunds or credits on damaged, opened or used merchandise after your first order and on subscribe & save orders.

Your order will not be eligible to return 30 days after the order date. If you are unable to complete this process or require further assistance, do not hesitate to email us at customercare@brunopharma.com, or to call us at 1-866-816-3400.

Instructions on how to return your order:

1. Access the brunomd.com and go to “Returns” (under info tab). Make sure your order is within 30 days from the purchase date.

2. You will be given a Returned Merchandise Authorization Number (RMA). No refunds will be given without an RMA number and package will be refused. RMA numbers will be valid for 10 days only. A refund will be issued upon approval of eligibility.

3. A pre-paid label will be email to you.

4. Write the RMA# on the outside of your shipping box.

5. Enclose a note with a copy of the original invoice/packing slip with the reason for the return and the RMA number. Carefully package the products in the original shipping box or any suitable shipping carton using plenty of padded material to protect the product(s). Make sure the products are well protected and packaged similar to the way you received them.

6. Ship your return package to:

Bruno Pharma innovations

Attn:

Returns Department

10268 WHITE WATER LILY WAY

BOYNTON BEACH,

FL

33437

US

7. A refund will be issued upon approval of eligibility. Keep accurate records and tracking numbers of your shipment until you have received your credit or new merchandise.

Access your account at www.brunomd.com, by clicking on the ‘person’ icon located next to the basket icon on the home page (top right-hand corner).

Don't worry we will get you out a replacement product ASAP.

• Please log into the returns portal (link located at the footer of the homepage) and create a returns request. A picture of the damaged or incorrect item(s) is always required. Please download your images in the returns portal, so that we can bring the matter up with the carrier. Your case will be sent to our customer care department, and one of our customer care advisors will get back to you with further instructions.

• Alternatively, you can contact our Customer Care department within 72 hours of receipt by email at customercare@brunopharma.com or by calling at 1-866-816-3400, Monday - Friday from 9:00 AM-6:00 PM EST, and we will gladly assist you. Leave a detailed message if you are directed to the voicemail, including your name, order #, email address, and phone#, and one of our customer care advisor, will get back to you as quickly as possible.

Shipping

We offer free standard ground shipping for all orders over $75.00. To qualify, your cart total must be $75.00 after any applicable discounts, and the order made within the United States. Free shipping is typically 3-5 business days once we ship out your product. We do our absolute best to ship out all orders within 24 hours of ordering Mon-Fri. We currently do not ship any products outside of the United States.

Once we ship out your order, we will email you the tracking info so you can follow the order during transit. Tracking times take 1-2 days to update once we ship your order. If you have any issues with delivery or the shipping address, please let us know. We are able to change the address before the order ships, but not after. So, if your order has not been shipped, you can always edit your payment method, shipping information, or order content. Access your order at www.brunomd.com by clicking on the 'log-in' link located at the top right-hand corner of the homepage above the cart icon. You will need to create an account if you did not do so at the time of purchase. We encourage you to use the same email address that was used when the purchase was made to link the order to your account. If an account has already been created simply log in using your email address and password. You can do this by clicking on the ‘log-in’ link located above the cart icon on the home page (top right-hand corner). You will be redirected to the order history page and on the order line there is an option to ‘cancel/edit’ your order.

Alternatively, you can contact our Customer Care department within 72 hours of receipt by email at customercare@brunopharma.com or by calling at 1-866-816-3400, Monday - Friday from 9:00 AM-6:00 PM EST, and we will gladly assist you. Leave a detailed message if you are directed to the voicemail, including your name, order #, email address and phone#, and one of our customer care advisors will get back to you as quickly as possible.

The moment we ship out your order, we will email you the tracking number and a link so you can follow all tracking updates via email. If you can't find the email, access your order at www.brunomd.com (top right of the homepage). You will need to create an account if you did not do so at the time of purchase. We encourage you to use the same email address that was used when the purchase was made to link the order to your account. If an account has already been created simply log in using your email address and password. You can do this by clicking on the ‘log-in’ link located above the cart icon on the home page (top right-hand corner). You will be re-directed to the order history page and on the order line, there is an option to ‘track’ your order.

We recommend using the 'shop' app to track your order via email or SMS. The link for this application is embedded in the shipping confirmation email and can be accessed by clicking the 'view your order' tab & by accessing the 'track order with Shop' button. You will have to download the app. This application is very convenient and provides regular shipping updates, a great way to stay in control!

Tracking typically takes 24 hours to update, but it is not uncommon for tracking to take 2-3 days to update. We do our best to ship out all orders within 1 business day of ordering. If we emailed you a tracking number, then your order has been shipped out of our warehouse. We recommend using the 'shop' app to track your order via email or SMS. The link for this application is embedded in the shipping confirmation email and can be accessed by clicking the 'view your order' tab & by accessing the 'track order with Shop' button. You will have to download the app. This application is very convenient and provides regular shipping updates, a great way to stay in control!

If we have not emailed you your tracking #, it means that your order has not been shipped. You are still in time to edit your shipping address.

- Access your order at www.brunomd.com (top right of the homepage). You will need to create an account if you did not do it at the time of purchase. Please use the same email address that was used when the purchase was made to link the order to the account. If an account has already been created simply log in using your email address and password. You can do this by clicking on the ‘person’ icon located next to the basket icon on the home page (top right-hand corner). You will be redirected to the order history page and on the order line there is an option to ‘edit’ your order.

If we did email you your tracking #, that means that your order has been shipped already.

- Please contact us by sending an email using our “Contact Us form” located on the homepage (bottom under the info tab), or by using the “Help” bottom, located on the homepage (bottom right side), and one of our customer care agents, will get back to you as quickly as possible.

The next step is to reach out to the local courier that made the final delivery. It is probably USPS. Find out by checking your tracking #, previously emailed to you. The local courier will be able to tell you if this was an error during the scanning process, and can reach out to the courier on the route. If they are unable to help you locate the package please contact us by sending an email using our “Contact Us form” located on the homepage (bottom under the info tab), or by using the “Help” bottom, located on the homepage (bottom right side), and one of our customer care agents, will get back to you as quickly as possible.

Returns & Cancellation Policy

The faster way to get an answer to your question is to first search for it in our website under “Learn”, or in the search slick on the top right side, next to the “person” icon located next to the basket icon on the home page (top right-hand corner).

If you cannot find the answer email customer care department at customercare@brunopharma.com, or call us at 1-866-816-3400, Monday - Friday from 9:00 AM-6:00 PM EST, and we will gladly assist you. If you are directed to the voicemail, do not worry. Leave a detailed message including your name, order #, email address and phone #, and one of our customer care agents, will get back to you as quickly as possible.

You can access your account at www.brunomd.com, by clicking on the ‘person’ icon located next to the basket icon on the home page (top right-hand corner).

Having trouble?

There are few reasons why you may not be able to access your account:

1. Your password is incorrect

2. Reset your password: https://brunomd.com/account/login

3. Your account was never activated via email

4. Search your email for: "Customer account activation"

5. Your account is under a different email address

6. Your account was never created

Still having trouble?

Do not hesitate to contact us, by sending an email using our “Contact Us" form located on the homepage (Bottom under Info Tab), or by using the “Help” bottom, located on the homepage (Bottom Right-Hand Side), and one of our customer care agents, will get back to you as quickly as possible.

We are confident you will be happy with your Bruno MD products; however, if for any reason you are dissatisfied with your purchase, we will refund your first order in full. We honor a full refund if our customer care department is contacted within 30 days from your first order date. There is no need to return the product; however, we welcome your feedback to help us improve the quality of our service.

You must create an account if you want to cancel your order. If an account was not created at the time of purchase, then one will need to be created. Please use the same email address used when the purchase was made to link the order to the account. If an account has already been created, simply log in using your email address and password. You can do this by clicking on the “person” icon located next to the basket icon on the home page (top right-hand corner). You will be redirected to the order history page, and on the order line, you will find the option to cancel/edit your order.

You will need to create a returns request via our returns center. This can be accessed using the following link: https://brunomd.myreturnscenter.com/

When you land on the returns center page, you will be prompted to input your order number and email address to start the returns process. Although our systems generate a Returned Merchandise Authorization Number (RMA), please ignore this as our policy is to refund your first order without you having to return the product. You will be refunded in full once our customer care department has processed your request.

Subscribe & Save orders are automatically sent 30 days after your first shipment and every 30 days after that unless previously modified by you via our website. If you wish to reschedule, amend or cancel via our customer service department, you must contact us at least ten days before the shipment is processed. Cancellations will only take effect after we have had sufficient time to allow us and our financial institution, using commercially reasonable (but not extraordinary) efforts, to act on this notice. Your order will not be eligible to return if it is not within 30 days from the purchase date. To receive a full refund, all subsequent orders or all subscribe & save orders must be returned unopened and sealed. We do not issue refunds or credits on damaged, opened, or used merchandise after your first order and on Subscribe & Save orders. Consult our Return Policy located at the bottom of the homepage, on Returns (under Info tab).

Access brunomd.com and go to “Returns” (under Info Tab). Make sure your order is within 30 days from the purchase date, or your return cannot be processed via our returns center. You will be given a Returned Merchandise Authorization Number (RMA). No refunds will be given without an RMA number, and the package will be refused. RMA numbers will be valid for 10 days only. A refund will be issued upon approval of eligibility. A pre-paid label will be email to you. USPS courier will be used as the preferred shipping company. Write the RMA number on the outside of your shipping box. Enclose a note with a copy of the original invoice/packing slip with the reason for the return and the RMA number. Carefully package the products in the original shipping box or any suitable shipping carton using plenty of padded material to protect the product(s). Make sure the products are packaged similarly to the way you received them. Ship your return package to:Bruno Pharma Innovations Attn: Returns Department8791 Cobblestone Point Circle Boynton Beach, FL 33472A refund will be issued upon approval of eligibility. Keep accurate records and tracking numbers of your shipment until you have received your credit.Upon receipt of your return, your refund will be processed if eligible within 7 business days. If the original order was purchased via credit card, your refund will be credited to that same account. The cardholder must be the purchaser.

We take great care when packaging your shipment. However, in the event your shipment arrives damaged, please log into the returns portal and create a return request. A picture of the damaged item is always required. Please download your images in the returns portal so that we can bring the matter up with the carrier. Your case will be sent to our customer care department, and one of our customer care agents will get back to you with further instructions.

Alternatively, you can contact our Customer Care Department, within 72 hours of receipt, by emailing customercare@brunopharma.com or calling 1-866-816-3400, Monday - Friday from 9:00 AM - 6:00 PM EST and we will gladly assist you. If you are directed to voice mail, please leave a detailed message that includes your name, order number, email address, and phone number, and one of our Customer Care Agents will get back to you as quickly as possible.

Products

Royal Collagen Peptides

1. Skin Health Improving - elasticity, hydration, fine lines, wrinkles, ligaments, and tendons

2. Bone Health Improving - bone stability, flexibility, and density

3. Nail Health Promoting - growth and health of fingernails

4. Hair Health Promoting - healthier hair growth

5. Joint Health Measurable -recovery of joint cartilage

Specific Collagen Peptides sourced from Italy, Germany, Great Britain,other EU countries.

Our Specific Collagen Peptides are a breakthrough because they are proven to stimulate the creation of new collagen at any age. The benefits are many: improved skin texture, glow, and elasticity, stronger nails, and more youthful hair with renewed luster and bounce. The advantages are not merely cosmetic. Specific Collagen Peptides increase collagen levels throughout the body to restore cartilage, so you'll move better, and increase bone density to keep your bones strong.

The vast majority of collagen products available on the market today do not address the issue of collagen biosynthesis (the body’s ability to create its own collagen.) They combat the problem of collagen degeneration by offering a supplement that focuses on offsetting the loss. Royal Specific Collagen Peptides both offset the loss and maximize stimulation of the human cell types responsible for collagen biosynthesis, giving the body “fuel” to create collagen and improve skin, hair, nail, joints, and bone health.

Royal Collagen Peptides work in two ways: first, they stimulate the activity of the fibroblasts. Fibroblasts are cell types that build fibers and molecular components of the connective tissue, giving the skin its structure and firmness. Activating the fibroblasts encourages the production of new collagen structures as well as the ones from hyaluronic acid. Hyaluronic acid can bind a great deal of water and is indispensable for tight, firmer-looking skin. This process takes some time, but with consistency and determination, your skin regains its natural tone and improves its moisture-storing capacity.

Royal Collagen Peptides provide the skin with its necessary “building blocks.” Their mode of action is exceptionally sophisticated. They perfectly resemble the fragments which form when skin collagen degrades. Our bodies recognize these peptides as degradation products and boost our collagen synthesis. Thanks to the considerably higher production of natural collagen, the skin can repair itself and replace what was lost through age and environmental influencers.

Connective tissue includes the skin, ligaments, tendons, cartilage, and joint cartilage, as well as the fasciae and blood vessels.Collagen is the main component of connective tissue and structural tissue and is found everywhere in the body. It gives bones, joints, tendons, ligaments, and muscles strength and flexibility. If the collagenous structures are degraded by heavy stress, like working out, or by the normal aging process, the function of all organs and tissues that depend on collagen are impaired. Ligaments and tendons weaken, muscle mass decreases, and the loss of vital cartilage tissue at the joints can lead to painful symptoms. Fibroblasts are cell types responsible for collagen biosynthesis in the connective tissue. They build fibers and molecular components of the connective tissue, giving the skin structure and firmness. Activating the fibroblasts encourages the production of new collagen structures as well as the ones from hyaluronic acid.

About 70% of our bones are made of inorganic minerals and 10% of water. Collagen makes up the remaining 20% and forms the basic framework of the bone to which calcium “attaches.” Imagine calcium as the concrete bridge and collagen as the steel core. Calcium provides the mineral component of the structure’s strength. For this reason, Royal Collagen Peptides’ consumption is essential for helping maintain bone health. If collagen is missed in your body, the degradation of bone mass along with the stability of high-density bone is compromised. Royal Collagen Peptides help support bone health and improve bone stability and flexibility by stimulating the activity of the osteoblasts, the cell types responsible for the collagen biosynthesis (absorption) in the bone.

Cartilage is a fundamental constituent of our joints. It acts as a shock absorber when two bones meet at the joint, allowing frictionless, smooth movement while protecting the bones and joints. Since cartilage is not connected to the bloodstream, it receives its nutrients via synovial fluid that acts like a lubricant film and supplies the sponge-like cartilage with nutrients. This works through movement and pressure. Exercise is essential for providing the cartilage with nutrients. Royal collagen peptides stimulate the activity of the chondrocytes. Chondrocytes are cell types responsible for the collagen biosynthesis in the cartilage. They produce and maintain cartilage matrix.

Collagen peptides are considered non-allergic. Their structure is very similar to that of the body’s natural collagen. For that reason, collagen peptides are not regarded as a foreign substance that must be combated, even in a very sensitive immune system. This is why medical sponges made of collagen are used in surgical procedures. For example, a surgeon uses them to stop bleeding and leaves them in place to continue to regulate blood flow after the operation. The surgeon simply sutures the incision, and the sponges are absorbed and degraded in the body in a few weeks. Nevertheless, if you suffer from allergies, we recommend consulting your healthcare professional before taking this product.

For people with diabetes who have to keep their blood glucose level under control, collagen peptides are ideal energy and protein sources. Royal Collagen Peptides support the functionality of collagenous structures in the skin, so they can also help improve healing time.

We recommend talking with your healthcare professional first before taking our product because nutritional needs vary when pregnant or breastfeeding.

Our Royal Collagen Peptides taste nothing like conventional protein powders and peptides. Because of their neutral taste and excellent dissolution properties, many customers mix theirs with breakfast cereal, yogurt, or cold drinks.

Like the other proteins, Royal Collagen Peptides have a caloric value of4 kilocalories per gram. Fat, for example, has 9 kilocalories per gram, and alcohol has no less than 7. If you take the recommended quantity of 2.5 grams of collagen peptides daily for your skin, that amounts to only 10 kilocalories.For muscle building and body toning, the recommended 15 grams totals up to 60kilocalories. Royal Collagen Peptides can increase and prolong the feeling of being full and counteract food cravings, which makes them ideal for weight management.

Yes. Inadequate collagen levels in the body make connective tissue moreprone to injury, so consuming Royal Collagen Peptides can help protect muscles,ligaments, tendons, joints, and bones.

Our Royal Collagen Peptides Proprietary Blend contains pharmaceutical grade Vitamin C, which is very sensitive to heat. The increased temperature rapidly boosts its degradation. Vitamin C is vital for the absorption of iron and the biosynthesis of collagen in the human body. That’s why we recommend consuming Royal Collagen Peptides with cold liquid, cold juice, smoothies, yogurt, cold soups, or salads.

Our collagen peptides are bovine sourced exclusively from trustedEuropean suppliers and not from multiple untraceable animal sources fromthird-world countries. Our bovines are subjected to the strictest of veterinaryinspections before being released for human consumption, ensuring that anycontamination of the final product is avoided.

Royal Collagen Peptides are carefully blended with a potent and completely natural form of Vitamin C. Clinical research has proven that skin health is significantly improved when taking a collagen supplement combined with Vitamin C. However, choosing the right source of Vitamin C is crucial.Clinical studies have shown that taking Vitamin C and collagen peptide supplements ensures a healthy biosynthesis of collagen within the whole body.

The vast majority of Vitamin C (ascorbic acid) used in supplements on the market today is synthetically or artificially manufactured, often in China.Our experts opted to use a vastly superior, wholly natural, and clinically proven source known as the Red Orange Complex® from Sicily. The Red Orange Complex contains a standardized powder extract obtained from the juice of three pigmented (Moro, Tarocco, and Sanguinello) varieties ofSicilian blood oranges that are exclusively grown in a particular area nearMount Etna volcano in Sicily.

Sicilian Blood Oranges come from the greatest blood orange trees in the world, grow on the side of the Mount Etna volcano, where climate and soil are perfect for this kind of tree. No one else in the world has access to it. Sicilians call this orange “the ultimate healthy fruit.”

It is well known that the human body consists mainly of water. Proteinsare the other major component. When referring to the heart, lungs, kidneys,liver, brain, skin, bones, and even most hormones and enzymes that areindispensable for metabolism, it is always the proteins that provide theirstructure and function. Collagen is the most abundant component in the humanbody, and therefore an essential component of human connective tissue. Thisextraordinary protein is also the central building block of the bones, joints,tendons, and many other tissues and structures. Collagen provides a structure for the body and its many organs and keepsthem “together” in the truest sense of the word. It is present nearlyeverywhere in the body, forming and connecting moving parts, like the bones,and in turn, the muscles, tendons, and ligaments with the bones.

Currently, we know of 28 different types of collagen. The human bodymainly consists of collagen types I, II, and III. Type I accounts for about 90%of the body’s total collagen content, mainly in the connective tissue of theskin, bones, and tendons. Type II accounts for joint cartilage, and type IIIaccounts for skin and muscles.

The body keeps itself young by breaking down old tissue and building new tissue. As we age, this process slows down. When our body breaks down collagen, these long chains are disassembled, by enzymes, into small “snippets'' for removal. This sends a signal to the body to start rebuilding. A young and healthy body reacts to build the required quantity, but as we age, our metabolism becomes weary, and these signals are no longer enough for the body, which is becoming sluggish. When we consume collagen peptides as a dietary supplement, we ingest just these collagen snippets but in more significant amounts. Our bodies are rapidly digesting and absorbing collagen, mainly in the form of the smallest units, single amino acids, but also partially in intact form as collagen peptides (collagen snippets). These collagen snippets reach the bloodstream and distribute throughout the body. Collagen peptides stimulate our body’s collagen production. The whole connective tissue metabolism comes to life. Taking the skin as an example, it can be shown that other vital components of skin structure, such as elastin and proteoglycans, are also produced in significant quantities. The dermis, the second layer of skin, is completely overhauled. At the same time, the degradation of the skin is slowed. In total, more collagen is being built up than broken down, and it is precisely this effect that many users describe as amore attractive, firmer, radiant complexion. The balance also shifts in other tissue types such as cartilage or bone:increased formation, slower degradation. This also explains why dietary supplements cannot produce visible or tangible results instantly. Our body needs time to adapt to these processes. It is important to note one thing, collagen peptides not only affect the symptoms but also address the causes of the problems directly.

We have come up with a method of cutting the snippets out of the long chain of amino acids “to size” in an exact way. Specific Collagen Peptides are optimized for different purposes and particular conditions.

Collagen molecules themselves are very large, so the body has difficulty using and absorbing them. Collagen peptides are obtained from collagen.Collagen peptides are collagen molecules cut smaller, allowing our body to make good use of them and their excellent bioavailability.

When we are young, our metabolism runs at full speed, and our body cells are constantly renewing themselves. The nutrient uptake works flawlessly, and the body’s production of essential substances helps to ensure that it gets everything it needs. But as we grow older, many processes in the body change.Our entire metabolism slows down, and the untack and processing of nutrients declines. Certain tissues within the body are no longer reproduced at the required levels. Cartilage tissue wears out, bones become more porous, blood vessels calcify and stiffen, and the skin loses its ability to store moisture.These aging processes cannot be stopped. They can, however, be influenced by physical activity and a targeted diet with nutritional supplementation.

The body can absorb collagen peptides efficiently because they are water-soluble and, unlike other proteins, have a straightforward peptide structure that is very easy for the body to work with. They are broken down with an enzymatic process called exogenous enzymatic hydrolysis and can be absorbed more quickly than natural collagen.

There are indeed a multitude of plant-based proteins, for example, soy and hemp. However, they cannot replace collagen peptides as nutritional supplements. Our body is not made of plant origin. In purely biological terms, we are “animals,” and the collagen peptides of warm-blooded animals correspond to our body’s collagen building blocks molecular structure. This means that our body recognizes them as quasi naturally-produced proteins and can easily absorb and utilize them.

Royal Collagen Peptides "Beauty from Within"

When we are young, our metabolism runs at full speed and our body cells are constantly renewing themselves. The nutrient uptake works flawlessly, and the body’s own production of important substances also helps to ensure the body’s gets everything it needs. We are bursting with strengths and youthfulness. But as we grow older, many processes in the body change. Our entire metabolism slows down and the untack and processing of nutrients decline. Certain tissues within the body are no longer reproduced at the required levels. Cartilage tissue wears out, bones become more porous, blood vessels calcify and stiffen. The blood flow decreases, and as a result neither the tissue nor the brain is optimally provided for. The skin loses its ability to store moisture. These aging processes cannot be halted or reversed. They can, however, be influenced by physical activity and a targeted diet with nutritional supplementation.

It is well known that the human body consists largely of water. Proteins are the other major component. When referring to the heart, lungs, kidneys, liver, brain, skin, bones, and even most hormones and enzymes that are indispensable for metabolism, it is always the proteins that provide their structure and function. Collagen is the most abundant component in the human body, and therefore the most important component of human connective tissue. This extraordinary protein is also the central building block of the bones, joints, tendons, and many other tissues and structures. Collagen provides a structure for the body and its many organs, and keeps them “together” in the truest sense of the word. It is present nearly everywhere in the body, forming and connecting moving parts, like the bones, and in turn, the muscles, tendons, and ligaments with the bones.

Currently we know of 28 different types of collagen. The human body mainly consists of collagen types I, II and III. Type I accounts for about 90% of the body’s total collagen content, mainly in the connective tissue of the skin, bones, and tendons. Type II accounts for joint cartilage, and type III accounts for skin and muscles.

When we are young, our body is busy day and night performing renovation work. It keeps itself young by breaking down old tissue, while at the same time building new tissue to replace old. As we age, this process slows down, but it never ceases. When our body breaks down collagen, these long chains are disassembled, by enzymes, into small “snippets'' for removal. This sends a signal to the body: “Attention! Bits of degraded collagen are floating around here; we have to start rebuilding.” A young and healthy body reacts promptly to build the required quantity. As we age, our metabolism becomes weary and these signals are no longer enough for the body, which is becoming sluggish. When we consume collagen peptides as a dietary supplement, we ingest just these collagen snippets, but in larger amounts. Our bodies are rapidly digesting and absorbing collagen, mainly in the form of the smallest units, single amino acids, but also partially in intact form as collagen peptides (collagen snippets). These collagen snippets reach the bloodstream and distribute throughout the body. Now the cells in our body, which are responsible for connective tissue/collagen metabolism, notice that there is an imbalance. It is like an alarm, “Attention! There are lots of collagen particles swimming about here, now we really have to get work and make even more collagen!” As the collagen supplements provide the amino acids, building blocks for collagen synthesis at the same time, they support the body twofold. In this way, collagen peptides stimulate our body’s own collagen production. The whole connective tissue metabolism comes to life. Taking the skin as an example, it can be shown that other important components of skin structure, such as elastin and proteoglycans, are also produced in great quantities. The dermis, the second layer of skin, is, so to speak, completely overhauled. At the same time the degradation of the skin is slowed. In total, more collagen is being built up than broken down, and it is exactly this effect that many users, mostly women, describe as a more attractive, firmer, radiant complexion. The balance also shifts in other tissue types such as cartilage or bone: increased formation, slower degradation. This also explains why dietary supplements cannot produce visible or tangible results instantly disappear. Our body needs time to adapt to these processes. It is important to note one thing, collagen peptides do not only affect the symptoms, but also address the causes of the problems directly.

We have invested a lot of time researching these differences and came up with a method of cutting the snippets out of the long chain of amino acids “to size’ in precisely the right way. Specific collagen peptides are optimized for different purposes, and for specific conditions.

Collagen molecules themselves are very large, which is why the body has difficulty in using and absorbing them. Collagen peptides are obtained from collagen. Collagen peptides are collagen molecules cut smaller allowing our body to make good use of them. Therefore, one speaks of their excellent “bioavailability”.

Collagen peptides can be so well absorbed by the body because they are water-soluble, and, unlike other proteins, have a very simple peptide structure, that is very easy for the body to work with. They are “broken down”, with an enzymatic process called “exogenous enzymatic hydrolysis” and can therefore be absorbed more quickly and extensively than under natural collagen.

The vast majority of collagen products available on the market today do not address the issue of collagen biosynthesis (the body’s ability to create its own collagen.) They combat the issue of collagen degeneration by offering a supplement that focuses on offsetting the loss. ROYAL Specific Collagen Peptides “Beauty from Within” both offset the loss & maximize stimulation of the human cell types responsible for collagen biosynthesis giving the body fuel to create collagen to improve skin, hair, nail, joints, and bone health*.

Royal Collagen Peptides work in 2 ways: firstly, they stimulate the activity of the fibroblasts. Fibroblasts are cell types that build fibers and molecular components of the connective tissue, thus giving the skin its structure and firmness. Activating the fibroblasts encourages the production of new collagen structures as well as the ones from the hyaluronic acid. Hyaluronic acid can bind a great deal of water and is indispensable for taut-looking skin (taut means tight, firmer). This process takes some time, but with consistency and determination, your skin regains its natural tone and improves its moisture-storing capacity. Furthermore, Royal Collagen Peptides provide the skin with the necessary “building blocks”. Their mode of action is extremely sophisticated. They perfectly resemble the fragments which form when skin collagen degrades. Our body “recognizes” the peptides as degradation products, and boosts the body’s own collagen synthesis. The result: Thanks to the considerably higher production of natural collagen, the skin can repair itself and replace what was lost through age and environmental influencers.

Connective tissue includes the skin, ligaments, tendons, cartilage and joint cartilage, but also the fasciae and blood vessels.

Collagen is the main component of connective tissue and structural tissue, and is found everywhere in the body. It gives bones, joints, tendons, ligaments, and muscles strengths and flexibility. If the collagenous structures are degraded by heavy stress, for example by working out, or by the normal aging process, the function of all organs and tissues that depend on collagen are impaired. Ligaments and tendons weaken, muscle mass decreases, and above all, the loss of highly important cartilage tissue at the joints can lead to painful symptoms. Fibroblasts are cell types responsible for collagen biosynthesis in the connective tissue. They build fibers and molecular components of the connective tissue, thus giving the skin structure and firmness. Activating the fibroblasts encourages the production of new collagen structures as well as the ones from the hyaluronic acid.

a. Improvement of Skin Health. Improving elasticity, hydration, fine lines, wrinkles, ligaments, and tendons*

b. Supporting Healthy Inflammation Response*

c. Improvement of Nail Health. Promoting growth and health of fingernails *

e. Improvement of Hair Health. Promoting healthy hair*

f. Improvement of Skin Tone. Helping Improve skin tone by reducing age spots *

g. Reducing appearance of cellulite. Helping smooth skin and increase elasticity of connective tissue with the dermal matrix to help decrease the appearance of cellulite*.

Royal Collagen Peptides® are carefully blended with a potent & completely natural form of vitamin C. Vitamin C is necessary for the biosynthesis of collagen in the human body. When collagen is produced, there is a complex series of events, some occurring inside of the cell, and some outside of the cell. Vitamin C is active inside of the cell, where it hydroxylates (adds hydrogen and oxygen) to two amino acids: proline and lysine. This helps form a precursor molecule called procollagen that is later packaged and modified into collagen outside of the cell. Without vitamin C, collagen formation is disrupted, causing a wide variety of problems throughout the body.

Clinical research has proven that skin health is significantly improved when taking a collagen supplement combined with Vitamin C. However, choosing the right source of Vitamin C is CRUCIAL. Clinical studies have shown that taking vitamin C along with collagen peptides supplements ensure a healthy biosynthesis of collagen within the whole body.

Harmful free radicals break down collagen in your skin and your skin’s ability to produce more collagen. Astaxanthin enhances collagen supplementation by protecting skin from free radicals and by preserving natural collagen production keeping skin hydrated, supple, and smooth.

When trio of key ingredients is taken together, they increase the collagen production in the skin cells by 108%.

Astaxanthin can protect existing HA molecules from free radical degradation. Furthermore, Astaxanthin has been shown to increase Hyaluronic production in keratinocytes at the epidermis. Keratinocytes are epidermal cells that produce keratin, the fibrous protein that constitutes hair and nails. This makes Bruno MD® Royal Collagen Peptides WITH Astaxanthin and HA a powerful combination for supporting hydration in aging skin.

1. Reduce Inflammation. From Haematococcus Pluvias Algae to reduce inflammation and restart collagen-producing cells. Astaxanthin is the most potent antioxidant known in nature. Your skin is under constant attack by free radicals, and astaxanthin acts as a defender to preserve collagen production, and lock in the increased elasticity and hydration. A group of 150 healthy women aged 20-55 supplemented with Astaxanthin over six separate studies.* The women taking Astaxanthin demonstrated an 18% improvement in viscoelasticity and 17x increase in skin hydration over the placebo group after just four weeks. Additionally, skin smoothness improved 16%, and age spots were reduced by an average of 3mm in only eight weeks.

2. Boost collagen production with Specific Collagen Peptides. From highly purified collagen peptides to stimulate fibroblasts, reduce wrinkles, and improve overall skin tone. Bruno MD collagen peptides begin with an organic, non-GMO, halal, and kosher certified bovine source, raised exclusively on a plant-based diet by European partners near the Alps. The EU prohibits ranchers from breeding genetically modified bovines or using GMO feed, unlike farmers in the farmers in the US and Brazil. Three clinical trials* conducted on 250 healthy females, ages 45 to 65, confirm that oral intake of Royal Collagen Specific Peptides Complex significantly reduced eye wrinkle volume by 20.1% on average and up to a maximum of $49.9% vs. the placebo group after only eight weeks of treatment.

3. Maximize collagen biosynthesis with Red Orange Complex from varieties of Moro, Sanguinello, and Tarocco orange extract to encourage collagen formation and boost the immune system with potent Natural Vitamin C. We harvest our Vitamin C from three varieties of blood orange grown for centuries on family farms near Mt. Etna volcano. This mineral rich soil creates citrus so dense in flavonoids and Vitamin C that the Romans called it “the miracle of Madre Terra”.

4. Lock in hydration with Hyaluronic Acid. From natural fermentation process which significantly increases skin plumpness, moisture, and glow. Hyaluronic Acid is a sponge that keeps our skin hydrated. Our Hyaluronic Acid is made with organic fermentation and is clinically proven to help reduce wrinkles, smooth skin texture, and deeply hydrate skin cells. A group of 120 healthy women aged 35-60 with dry and sagging skin or wrinkles around their outer canthus supplemented with Bruno MD low molecular weight hyaluronic acid for six weeks and significantly increased skin moisture content and improved the facial aging symptoms such as luster and suppleness. Also, the group showed better levels of the sulcus volume ratio, wrinkle area ratio, and wrinkle volume ration than the placebo group.

Our collagen peptides are bovine source only, exclusively from trusted European suppliers, and not from multiple untraceable animal sources from third world countries. Our bovines are subjected to the strictest of veterinary inspections prior to being released for human consumption ensuring that any contamination of the final product is avoided.

The vast majority of Vitamin C (ascorbic acid) used in supplements on the market today is synthetically or artificially manufactured, mostly in China. Our experts opted not to use this cheap source and instead decided to use a vastly superior, completely natural and clinically proven source known as the Red Orange Complex® from Sicily. The Red Orange Complex® contains a standardized powder extract obtained from the juice of three pigmented (Moro, Tarocco, and Sanguinello) varieties of Sicilian blood oranges that are exclusively grown in a particular area surrounding the Mount Etna volcano in Sicily (Italy).

Astaxanthin is a naturally occurring pigment that gives the reddish pink color to marine organisms such as crabs, shrimp, and salmon. It is often called the “King of Carotenoids” because of its powerful antioxidant potency. Astaxanthin also possesses a unique molecular structure that spans the cell membrane’s hydrophilic and hydrophobic layers, attracting and quenching free radicals. Our natural Astaxanthin is derived from a wholly natural source, the microalgae Haematococcus pluvialis, and contains the same form of astaxanthin found in wild salmon. Our natural astaxanthin is produced in Japan and Sweden.

Astaxanthin is made by the algae Haematoccous pluvialis in response to stresses that produce free radicals. Astaxanthin is called a “secondary carotenoid” because algae make it using beta-carotene as one of the starting materials for making astaxanthin. Astaxanthin is fat-loving organic hydrocarbon with the chemical formula C40H52O4. It has a central chain of carbons with alternating single and double bonds (also known as conjugated double bonds), which is a special structure that allows astaxanthin to neutralize free radicals. The oxygen-containing rings at each end of the astaxanthin molecule fit on the edges of cell membranes, giving astaxanthin the unique ability to span the whole membrane for full protection from free radical damage.

Our natural astaxanthin is only produced indoors in a clean, controlled environment where the air is filtered through hospital grade HEPA filters and use only triple, reverse osmosis purified water. While others produce their astaxanthin outdoors, this does not allow much control over the environment, which can cause the quality of the astaxanthin produced to be compromised. Strict manufacturing processes allow our strategic business partner to control the light, water, air, and nutrients, and therefore to produce the cleanest, and most stable natural astaxanthin in the world.

Our Hyaluronic Acid is sourced in Japan and is produced with a natural microbial fermentation process. The safety of Hyaluronic acid produced by the microbial fermentation through our quality assurance system is developed in the manufacture of pharmaceuticals. The production bacillus used in the fermentation method is Streptococcus zooepidemicus, listed in basic principles, manufacturing methods, and characteristics under “Food additive —Hyaluronic acid.

There are indeed a multitude of plant-based proteins, for example, soy and hemp. However, they cannot replace collagen peptides, as nutritional supplements. The explanation is quite simple, our body itself is not made of plant origin. In purely biological terms, we are, we are also “animals”- the collagen peptides of warm-blooded animals correspond to our body’s own collagen building blocks in their molecular structure. Our body recognizes them as quasi naturally produced proteins and can easily absorb and utilize them.

Absolutely! For diabetics who have to keep their blood glucose level under control, collagen peptides are an ideal source of energy and of protein. Many diabetics also suffer from poor wound healing. Collagen peptides have a positive effect in this case, because when the functionality of collagenous structures in the skin is supported, collagen can also improve wound healing.

We always recommend talking with your doctor first, before consuming our product, as nutritional needs can vary when you are pregnant or breastfeeding.

Collagen peptides are considered non-allergic. Their structure is very similar to that of the body’s own natural collagen. For that reason, collagen peptides are not regarded as a foreign substance that must be combated, even in a very sensitive immune system. This is why medical sponges made of collagen are used in surgical procedures. For example, a surgeon uses them in the body to stop bleeding and leaves them in place so that they can continue to regulate the blood flow; even after the operation. The surgeon simply sutures the incision, and the sponges are simply absorbed and degraded in the body just in few weeks without any reactions occurring. Nevertheless, if you suffer from allergies, we recommend you consult your healthcare professional before taking this product.

Our collagen peptides have a mild flavor of their own, however this is nothing like the taste of conventional protein powders and peptides. Because of their neutral taste, and the excellent solubility and dissolution properties, many customers can mix Royal collagen peptides with breakfast cereal, drinks, yogurt and any cold drinks.

Like the other proteins, Royal Collagen Peptides have a caloric value of 4 kilocalories per gram. Fat, for example, has 9 kilocalories per gram, and alcohol has no less than 7. So, if you take the recommended quantity of 2.5 grams of collagen peptides daily for your skin, that amounts to only 10 kilocalories. For muscle building and body toning, the recommended15 grams totals up to 60 kilocalories. But here comes the best news: Royal Collagen Peptides can increase and prolong the feeling of being full and counteract food cravings, which makes them ideal for weight management.

Yes. Royal Collagen Peptides help protect muscles, ligaments, tendons, joints and bone. Inadequate levels of collagen in the body make connective tissue more prone to injury.

Our Royal Collagen Peptides® Proprietary blend contains pharmaceutical grade Vitamin C which is very sensitive to heat, therefore, increased temperature rapidly boosts its degradation. Vitamin C is vital for the absorption of iron and the biosynthesis of collagen in the human body. For best results: Add 1 packet to at least 8 fl oz. of cold water, and mix well. Royal Collagen Peptides may be consumed with or without food, at any time during the day.

Riboflam

Riboflam contains clinically proven ingredients to promote a healthy inflammation response and gain relief from exercise-related pain. Other benefits include:

1. Healthy Whole Body Inflammation Response - maintains and moderates inflammation response.

2. Immune System Functionality - boosts and speeds immune response

3. Brain Health - supports mental health, cognition, mental clarity, and focus

4. Post Exercise Pain - helps ease muscular pain related to sports activity

5. Digestive and Liver Function - supports intestinal health and maintains liver health ***

6. Social Functions - helps maintain the performance of social and emotional functions.

Yes, Riboflam is a vegan dietary supplement. It is made from plant-based ingredients right down to the capsules. This allows everyone to take the supplement regardless of personal or religious dietary restrictions.

We recommend talking with your doctor before consuming our product, as nutritional needs can vary when you are pregnant or breastfeeding.

Take three (3) capsules daily: 1 in the morning, 1 in the afternoon, and 1 in the evening, preferably before meals or as directed by your healthcare professional.

Riboflam is a blend of ingredients that contain a Nucleotides Complex, Natural Astaxanthin, Curcumin Phytosome, Boswellia Serrata Phytosome, and Echinacea Angustifolia Phytosome, all of which are clinically proven.

Bruno MD Riboflam is a powerful combination of clinically proven ingredients that have been validated in more than 120 double-blind, placebo-controlled studies. It has also been proven to have long-term high tolerability in an 18-month clinical trial.

It is a patented technology that vastly improves the bioavailability of our products, including Bruno MD Riboflam. Phytosome technology is the only nutrient delivery system in the world that can claim a 100% food-grade composition and delivers the highest concentration of vital nutrients where your body needs them in their most potent form.

This technology makes our prescription-grade ingredients Ultra-Bioavailable. Bioavailability is the amount of a substance that enters your bloodstream. Bioavailability is key to keeping you in the game by ensuring fast recovery and long-term inflammation management.

Our formulation begins at the cellular base level with a unique Nucleoflam™ Proprietary Nucleotide & Nucleosides Yeast Extract Complex. These nucleotides are vital to maintaining essential cell functions and supporting a healthy immune system, digestive system, and brain function. Nucleotides yeast extracts are a natural product extracted from yeast cells with a gentle, standardized, and highly controlled process free of chemical solvents. They are defined as low molecular weight intracellular compounds that participate in numerous biochemical processes. They serve several functions in human cells:

Structural (nucleic acids - RNA, DNA)

Carriers (energy transport – ATP, ADP, AMP)

Co-Enzymes (key role in the synthesis of proteins, fats, and carbohydrate metabolism)

Messengers (intracellular signal transduction)

They are a source of nucleotides, nucleosides, oligonucleotides, ribonucleic acid fragments, amino acids, minerals, and group B Vitamins. They are gluten-free and suitable for vegans. They are certified as both kosher and halal.

Nucleotides yeast extracts can support immune system functionality, gut barrier health, sports nutrition (recovery after performance), cognition/concentration (lack of synthesis of nucleotides in brain tissue), and iron absorption. They can also boost the anti-inflammatory activity of Acerola (Vitamin C), Zinc, and Vitamin D3.

Our astaxanthin is a naturally occurring carotenoid derived from the microalgae “Haematococcus Pluvialis” found in temperate environments worldwide. Astaxanthin has a unique molecular structure that makes it hundreds of times more potent than any other antioxidant molecule. For this reason, Astaxanthin is often called "The King of Antioxidants." As well as being the most powerful antioxidant known to science, Astaxanthin also has powerful anti-inflammatory properties. It can span the entire lipid bilayer of the cell membrane, thus providing superior protection from the inside out.

Studies have shown that natural Astaxanthin may provide significant protection to the mitochondria, preventing muscle damage.

Over 50 human studies, including 23 double-blind, placebo-controlled trials with more than 1,400 participants undergoing treatments lasting from 2 weeks to 6 months, have been performed.

Research has shown that natural Astaxanthin is a potent anti-inflammatory and is particularly effective against chronic inflammation.

Our immune system is a complex network of specialized cells and organs that work together to protect the body against infections from bacteria, viruses, and other outside invaders. With age, the activity of the immune system declines and becomes more vulnerable to oxidative stress. The most pronounced decline is found in cell-mediated immune response, especially a decline in the proliferation capacity in T-lymphocytes.

B cell phagocytes are cells that ingest and destroy harmful pathogens such as bacteria and viruses, while T cell lymphocytes assist antibody release, destroying virus-infected cells and helping to remember and recognize previous invaders.

Clinical results have shown that Natural Astaxanthin seems to increase the count of these two major components of the immune response (the B lymphocytes and the T phagocytes.)

Riboflam’s formula contains clinically proven flavonoid phytosomes: Turmeric Extract (Curcuma Longa), Indian Frankincense (Boswellia Serrata), and Coneflower Extract (Echinacea Angustifolia).

It is a distinctive yellow spice, part of the ginger family (Zingiberaceae), used for thousands of years in Southeast Asia, China, and India for cooking and medicinal uses. Advances in modern medicine have revealed curcumin to be the key ingredient responsible for turmeric's activities and therapeutic properties. Turmeric has been used for thousands of years as a “master switch” for addressing the natural inflammation response function. Our Curcumin Phytosome is clinically proven in 35 randomized, double-blind, placebo-controlled, published clinical trials.

Turmeric works through multiple pathways and on more than one target to promote a normal inflammatory response, boost immune response, and provide relief from exercise-related pain. Curcumin Phytosome is based on a natural and food-grade delivery Phytosome technology. The extract has been standardized, and it contains the full bouquet of curcuminoids, not just curcumin (Curcuminoids are polyphenolic pigments and include 77% curcumin). Curcumin Phytosome is the #1 doctors’ recommended Curcumin, and it has been endorsed by Cleveland Clinic.

Boswellia Serrata Phytosome is derived from Indian Frankincense, a botanical extract taken from the gum resin of the Boswellia Serrata tree. Boswellia extract has been demonstrated to effectively manage various inflammatory response functions, including those in the bowel, joints, bones, respiratory airways, and brain. Its mechanism of action involves the modulation/control of the natural inflammatory response.

Boswellia Serrata Phytosome has been demonstrated to be useful for bowel-related inflammatory responses. It Improves physical function in subjects with joint and tendon challenges. Boswellia Serrata Phytosome has been shown to support gut health and significantly alleviate IBS (Irritable Bowel Syndrome) and IBD (Inflammatory Bowel Disease). In addition, clinical studies have shown that a cocktail of AKBA (Acetyl-11-Keto-𝛃-Boswelliac Acid) and Curcumin significantly inhibit certain viral infections (viral entry) compared to the untreated control.

Bruno MD Boswellia Serrata Phytosome extract has four times the bioavailability of regular Boswellia, which helps govern inflammatory response in the joints, bones, respiratory airways, the bowel, and the brain.

We use a variety of Echinacea Angustifolia (or Coneflower) root extract to create Echinacea Angustifolia Phytosome. The benefits of Coneflower can be traced back to the Native Americans who used it as a natural anti-inflammatory. Bruno MD’s strict agricultural controls guarantee plants high in polysaccharides with very low cross-contamination between Echinacea species. Echinacea Angustifolia Phytosome is optimized for maximum absorption.

Results in clinical trials conducted using our triple-standardized Echinacea Phytosome, have shown a statistically significant tendency to be more efficacious than flu vaccination alone, suggesting that E. Phytosome has the potential to act synergistically with influenza vaccination.

Multiple clinical studies substantiate all advertised health benefits and claims.

All clinical trials conducted on our ingredients are randomized, double-blind, placebo-controlled, and published.

Clinically proven claims represent the highest medical bar for any benefit and are rarely used on nutraceutical products.

The efficacy of our clinically proven ingredients is guaranteed.

Riboflam undergoes the same rigorous manufacturing and internal regulatory processes as our pharmaceutical drugs.

Inflammation is a buzzword that really means stress. Bruising and swelling, for example, are signs that inflammation is tending to an injury. But when inflammation doesn’t turn off, this long-term stress can lead to serious health problems.

The immune system is made up of two armies of cells; innate and acquired. Innate immune cells are the body's first line of defense. They quickly respond to foreign cells to fight infection, battle a virus or defend the body against bacteria. Our acquired immunity—also called adaptive immunity—uses T-cells and B-cells when invading organisms slip through that first line. These cells take longer to develop because their behaviors evolve from learned experiences, but they tend to live longer than innate cells. Adaptive immune cells remember foreign invaders after their first encounter and fight them off the next time they enter the body. This is the fundamental premise for how vaccines work—using a small, harmless amount of protein from a disease to allow the immune system to recognize that protein if the pathogen were to invade the body.

B-cells and T-cells are also called lymphocytes. "There are primary and secondary lymphoid organs involved in the complex development of lymphocytes,” says Pamela Crilley, DO, Chair of the Department of Medical Oncology at Cancer Treatment Centers of America (CTCA). “The primary lymphoid tissues in the initial generation of B- and T-lymphocytes are the bone marrow and the thymus.”

B-cells fight bacteria and viruses by making Y-shaped proteins called antibodies, which are specific to each pathogen and are able to lock onto the surface of an invading cell and mark it for destruction by other immune cells.

There are two main types of T-cells; helper T-cells and killer T-cells. Helper T-cells stimulate B-cells to make antibodies and help killer cells develop. Killer T-cells directly kill cells that have already been infected by a foreign invader. T-cells also use cytokines as messenger molecules to send chemical instructions to the rest of the immune system to ramp up its response.

While both are critical to the body's defense against disease and infection, T-cells and B-cells play very different roles.

Our body’s ability to fight infection and disease depends on our immune systems. The immune system is comprised of cells, tissues, and organs that work together to protect your body from illness and infection.

Since the immune system is not just a single entity, there isn’t a single food that you can eat or add to your diet to support it. The best way to keep your immune system running smoothly is to follow healthy living strategies that include.

Good Nutrition

Good nutrition is vital to supporting a healthy immune system. Follow a plant-based, heart-healthy menu that incorporates a variety of vegetables and fruits, whole grains, lean protein, and healthy fats. Eat small, frequent meals throughout the day to stay energized and ensure your body is getting enough calories, proteins, and nutrients.

Phytochemicals

Fruits, vegetables, and other plants contain a naturally occurring compound known as phytochemicals (or phytonutrients). Phytochemicals refer to a variety of compounds that give fruits and vegetables their color and flavor. Studies show that phytochemicals support the:

Immune system

Creation of healthy cells

Death of damaged cells. Phytochemicals also act as antioxidants to protect the body from damage.

Dietary Supplements

Dietary supplements help you get adequate amounts of essential nutrients if you don’t eat a nutritious variety of foods or if these nutrients cannot be taken from the food itself. However, make sure to always take dietary supplements that follow the highest standard quality control process. The FDA has established good manufacturing practices (GMPs) that companies must follow to help ensure the identity, purity, strength, and composition of their dietary supplements. These GMPs can prevent adding the wrong ingredient (or too much or too little of the correct ingredient) and reduce the chance of contamination or improper packaging and labeling of a product. The FDA periodically inspects facilities that manufacture supplements.

Lifestyle

Change your lifestyle to help support your health and immunity.

Get Enough Sleep

Sleep is an essential aspect of health. Our bodies need sleep to recharge and heal. The Centers for Disease Control and Prevention (CDC) recommends that adults get seven hours or more of sleep every night.

Minimize Stress

Stress can also take a toll on the immune system. In many ways, mental health can also affect your physical health. Try to reduce stress by taking time to do things you enjoy, such as spending time with family, spending time outdoors, or reading. If your feelings of anxiety or depression make it difficult for you to complete daily tasks, talk to your healthcare professional.

Exercise Regularly

Leading an active lifestyle can also support your immune system by promoting good circulation, allowing the cells and substances of the immune system to move through the body freely and do their job efficiently. Regular exercise promotes good cardiovascular (heart) health, too. The American Institute for Cancer Research (AICR) recommends getting at least 150 minutes of moderate activity or 75 minutes of vigorous physical activity a week. Physical activity includes walking, jogging, swimming, biking, playing sports, etc. Include strength training and stretching along with aerobic exercise to build muscle and increase flexibility.

Enjoy Life

Enjoy family, entertaining old friends, and making new ones; turn the simplest occasion into a social gathering for the entire neighborhood.

CholestQ10

CholestQ10 contains clinically proven ingredients to help reduce cholesterol counts while also providing several other health benefits, including:***

1. Cholesterol Health - supports healthy cholesterol levels

2. Cholesterol Control - inhibits cholesterol biosynthesis and LDL oxidation already in the healthy range

3. Cholesterol Inhibition - inhibit fat accumulation in the hepatocytes (liver cells)

4. CoQ10 Boost - significant boost of physiological CoQ10. 116% higher CoQ10 levels vs. baseline

5. Circulatory Management -supports healthy blood vessel function

It is a powerful antioxidant that protects proteins, LDL cholesterol, and mitochondrial DNA from oxidative damage.

As a participant in cellular energy production, CoQ10 helps ensure thebody’s biggest energy consumers, the heart and the brain, are well fed. Thanks to these two functions, CoQ10 can enhance cardiovascular functions.

CoQ10 Phytosome promotes healthy aging, heart & cardiovascular health, brain health, and all activities involving energetic expenditure. CoQ10Phytosome is delivered in a crystal-free preparation to maximize absorption.

Worldwide, heart-related diseases are at an all-time high. While many countries offer programs to help individuals reduce their cholesterol and blood pressure levels, these efforts simply cannot overcome the effects of poor diet and nutrition.

The ingredients we choose for CholestQ10 follow our core belief of good things coming from goodingredients.

Yes. CholestQ10 is a vegan dietary supplement. It is made fromplant-based ingredients right down to the capsules. This allows everyone to take the supplement regardless of personal or religious dietary restrictions.

We always recommend talking with your healthcare professional before consuming our products, as nutritional needs can vary when pregnant or breastfeeding.

Take two (2) capsules daily, 1 in the morning, and 1 in the evening,preferably before meals or as directed by your healthcare professional.

CholestQ10 is a blend of ingredients that contain Vitamin E (asd-alpha-tocopherol succinate), Bergamot Phytosome, Curcumin Phytosome, CoenzymeQ10 Phytosome, and Cardoon.

It is a powerful combination of clinically proven ingredients that have been validated in more than 120 double-blind, placebo-controlled studies. It has also been proven to have long-term high tolerability in an 18-month clinical trial.

CholestQ10’s formula contains clinically proven flavonoid phytosomes: Bergamot Orange extract (Citrus Bergamia), Turmeric Extract (Curcuma Longa), and Coenzyme Q10.

We use a variety called Citrus Bergamia Risso et Poiteau, an endemicplant of the Calabrian region of Southern Italy. Bergamot Phytosome isclinically proven to protect against cardiovascular issues by supporting healthy cholesterol levels. It also helps govern metabolic conditions that increase the risk of heart disease and TYPE II diabetes. Bergamot Phytosome optimizesthe biological absorption of polyphenols, which are normally characterized by poor solubility in both water and organic solvents. Our Citrus Bergamia is the green “gold standard” for heart health.

Bergamot Orange Extract is acitrus fruit. Bergamot Orange Extract (Citrus Bergamia) is hand-harvested in Calabria.

It is a distinctive yellow spice, part of the ginger family(Zingiberaceae), used for thousands of years in Southeast Asia, China, andIndia for cooking and medicinal uses. Advances in modern medicine have revealed curcumin to be the key ingredient responsible for turmeric's activities andtherapeutic properties. It has been used for thousands of years as a “masterswitch” for addressing the natural inflammation response function. Our CurcuminPhytosome is clinically proven by 35 randomized, double-blind,placebo-controlled, published clinical trials.

Curcumin Phytosome works through multiple pathways and on more than onetarget to promote a normal inflammatory response, boost immune response, and help reduce exercise-related pain. It is delivered with Phytosome technology. The extract has been standardized, and it contains the full bouquet ofcurcuminoids, not just curcumin. (Curcuminoids are polyphenolic pigments andinclude 77% curcumin). Curcumin Phytosome is the #1 doctors’ recommended Curcumin, and it has been endorsed by the Cleveland Clinic.

With Curcumin Phytosome, the level of bioavailability, absorption,modality, and tolerability over time make our product compatible andappropriate to the permanent role of “Life Guardian” over the levels of chronic inflammation during the entire course of life.

Our Curcumin Phytosome is sourced from India.

Coenzyme Q10 (CoQ10) is a potent antioxidant. CholestQ10 is formulated with Phytosome proprietary technology, a revolutionary ingredient transport system that delivers 100% food-grade composition of vital nutrients in their most potent form, where your body needs them. Coenzyme Q10 is delivered in a crystal-free liquid solution to maximize absorption. CoQ10 Phytosome promotes healthy aging, heart and cardiovascular health, brain health, and all activities involving energetic expenditure.

Our Coenzyme Q10 Phytosome is sourced in Lombardia, Italy.

Both natural-sourced Vitamin E and synthetic Vitamin E are absorbed in the body. However, after absorption, a specific transport protein in the liverknown as RRR-alpha-Tocopherol Transport Protein (α-TTP) recognizes the naturald-alpha-tocopherol acetate. It gives it priority over the synthetic form. The unrecognized form of synthetic Vitamin E is preferentially excreted. Vitamin Ein natural form is retained better and longer in the body when compared to thesynthetic form. As a result, Vitamin E natural Tocopherol is more efficientlyused by the body than its synthetic counterpart and has higher bioavailability.

Together they are a heart-healthy duo that stays active in the body longer and creates a paving shield to protect proteins, LDL cholesterol, and mitochondrial DNA against the oxidative damage that leads to heart disease.

Farmers have grown an artichoke called the Cardoon in Sicily. Bruno MDscientists discovered that the active biophenols and flavonoids from an endemicvariety of Cardoon leaf (Cynara Cardunculus L. Var. altilis DC and scolymus) are among the most potent found in nature. Importantly, these compounds inhibit the creation of fatty lipids in the hepatocytes (liver cells), a “secret” health benefit that farmers have known for millennia.

Our Cardoon Leaf Extract is sourced in Italy.

- Multiple clinical studies substantiate all advertised health benefits and claims.

- All clinical trials conducted on our ingredients are randomized, double-blind, placebo-controlled, and published.

- Clinically proven claims represent the highest medical bar for any benefit and are rarely used on nutraceutical products.

- The efficacy of our clinically proven ingredients is guaranteed.

- CholestQ10 undergoes the same rigorous manufacturing and internal regulatory processes as our pharmaceutical drugs.

Yes. All our key ingredients are exclusively sourced from trusted suppliers. Other brands often obtain their key ingredients from multiple untraceable animal sources and often from third-world countries.

BlueRex Vision

1. Blue Light Damage Proven - eye protection from harmful blue light

2. Dry, Itchy Eyes - supports healthy tear secretion

3. Digital Eye Strain Support - alleviates oxidative stress in eyes and symptoms of (CVS) computer vision syndrome

4. Eye Pain From Prolonged Screen Time - reduces eye fatigue and strain. Promotes vision recovery from digital overexposure.

6. Total Eye Care - helps maintain overall eye health

Bluerex Vision is the only eye health dietary supplement that helps with Blue Light Protection and Relief from Computer Vision Syndrome (CVS). It contains clinically proven ingredients to increase Macular Pigment Optical Density (MPOD) and support eyes from front to back.

Bluerex Vision protects the back of the eye with Lutein and Zeaxanthin, which help filter out harmful blue light and promote vision recovery from overexposure to fluorescent light and computer monitors. Bluerex Visionprotects the front of the eye with natural Astaxanthin, which helps reduce eye fatigue and strain, alleviating oxidative stress and symptoms of Computer Vision Syndrome. Bluerex Vision’s Bilberry Extract has demonstrated its efficacy in supporting healthy tears secretion. At the same time, Vitamin E (d-alphatocopherol) helps neutralize oxidation and protect the parts of the eye which are particularly susceptible to oxidative damage.

Bluerex Vision contains clinically proven ingredients to increase Macular Pigment Optical Density while also providing several other health benefits, including eye protection from harmful blue light. Bluerex Vision supports healthy tear secretion, alleviates oxidative stress in eyes and symptoms of Computer Vision Syndrome, reduces eye fatigue and strain, promotes vision recovery from overexposure to fluorescent lighting and computer monitors, and helps maintain overall eye health.

Bluerex Vision increases ciliary muscle recovery and endurance, improving the capillary blood flow, and inhibiting inflammation. Astaxanthin inthe Bluerex Vision works to protect the front of the eye to help alleviateoxidative stress and reduce Computer Vision Syndrome symptoms.

Bluerex Vision guards the body against the damaging effects of free radicals, working as light filters and as antioxidants in the eye. Lutein &Zeaxanthin in Bluerex Vision’s blend protect eyes from harmful blue light andhelps maintain protection at the back of the eye. Lutein & Zeaxanthin alsopromote vision recovery from overexposure to fluorescent light and computer monitors.

Bluerex Vision proprietary complex is a powerful combination of clinically proven ingredients verified through more than 130 double-blind studies. Ingredients include Bilberry Extract, Natural Vitamin E(d-alpha-tocopherol), Docosahexaenoic acid (DHA), Natural Astaxanthin, Lutein, and Zeaxanthin

Our Lutein & Zeaxanthin combo is clinically proven to protect the back of your eyes. These all-natural compounds are harvested from marigold flowers and dramatically increase the macular pigments critical to filtering harmful blue light before it can damage your retina. Lutein & Zeaxanthinare clinically proven partners to help reduce the progression of certain eye issues throughout our lives.

Lutein & Zeaxanthin are not made by the human body and must come from the food we eat. Most people do not eat enough Lutein & Zeaxanthinthrough their diet and need to fill the gap with dietary supplements. Hundreds of studies have shown that nutritional supplements containing Lutein & Zeaxanthin help keep eyes healthy, improve visual performance, and reduce the progression of certain eye conditions as we age.

Lutein & Zeaxanthin work as light filters and antioxidants in the eye. Lutein primarily accumulates where rods are the dominant photoreceptors. Rods allow for low light vision, sensitive motion detection, and peripheralvision. Zeaxanthin primarily accumulates where cones are the dominant photoreceptors. Cones allow for color and the ability to see the contrast between two objects. Working together, Zeaxanthin & Lutein absorb a broader bandwidth of blue light from digital devices, LED lights, and sunlight than either alone. Both support the back of the eye and help filter harmful bluelight, and improve night vision and contrast sensitivity.

Studies have shown Astaxanthin to increase ciliary muscle recovery andendurance. Additionally, it improves capillary blood flow and blood rheology.

Our Natural Astaxanthin is clinically proven to help shield the front of your eyes: it’s nature’s most potent antioxidant, sourced from special algae called Haematococcus Pluvialis found in temperate regions around the world. The microalgae accumulate astaxanthin in lipid vesicles during periods of nutrient deficiency and environmental stress. Because Haematococcus Pluvialis often grows in places exposed to intense sunlight during its dormant phase,astaxanthin functions to protect the cell nucleus against free radicals generated by UV radiation and strengthen the eye muscles, to reduce eye fatigue that contributes to Computer Vision Syndrome.

Astaxanthin is perfectly designed to protect the mitochondria. It protects the inner part of the membrane made by lipids that flows into the center and protects the outside of the membrane made up of hydrophilic protein molecules. Antioxidants like Vitamin C, Vitamin E, and beta carotene can’t do the same job. They don’t have the right shape, the right length, or the rightamphiphilic (compounds possessing both hydrophilic (water-loving, polar) and lipophilic(fat-loving) properties), qualities that allows astaxanthin to both span the hydrophobic center of the membrane and anchor in the hydrophilic molecules. In other words, Bluerex Vision’s Astaxanthin has the ability to span the entirelipid bilayer of the cell membrane, thus providing superior protection from the inside out.

Astaxanthin has the purest antioxidant molecule because it has no pro-oxidant activity (natural antioxidants can act as pro-oxidants, whichproduce free radicals and cause DNA damage and mutagenesis) even when subjected to an enormous amount of stress from environmental factors and free radicals.

Bluerex Vision’s Astaxanthin is more potent than other antioxidants when combating singlet oxygen damage for eye health. Singlet oxygens are active oxygen species generated in human skin by exposure to ultraviolet radiation(UV) that causes eye damage. To give you a measure of the potency of ourproduct, Bluerex Vision’s Astaxanthin is 6,000 times stronger than Vitamin Cand 3,000 times stronger than Resveratrol.

We only use Natural Astaxanthin extracted from the algae Haematococcus Pluvialis because this particular astaxanthin extract is the most potent form of astaxanthin. Most other products opt to use a cheaper synthetic alternative. The main issue with using this synthetic option is that it has a different molecular profile to natural astaxanthin. While the only clinical study on synthetic astaxanthin indicates it may have some health benefits, little clinical research has been done to measure its effectiveness compared to natural astaxanthin. Some research even suggests that Natural Astaxanthin is 20 to 60 times more potent than its synthetic variant. Very few products on the market today use Natural Astaxanthin extracted from the algae H. Pluvialis.

We cultivate our astaxanthin using proprietary indoor, state-of-the-art photobioreactors, using triple-filtered water and air to eliminate contaminants such as bugs, pollution, and weather. For other brands, cultivation is not conducted indoors and is often subject to contamination.

Our Natural Astaxanthin is extracted at full maturity and is chlorophyll-free. Chlorophyll can interfere with the stability of astaxanthin. Certain products in other brands contain chlorophyll which can interfere with the stability of astaxanthin.

Our Natural Astaxanthin is cultivated using sustainable energy sources that minimize energy and water loss due to evaporation and space while protecting against environmental pollutants.

Our Natural Astaxanthin is a USP verified dietary supplement produced 100% in the USA, from cultivation to extraction.

Lastly, our Natural Astaxanthin has been third-party tested as free of PAH carcinogens or skin irritants like pheophorbide. Testing guarantees our astaxanthin is safe. Other companies use sources of astaxanthin with low-quality control procedures, which can drastically reduce the efficacy of the product and increase the chances of contamination.

- Astaxanthin can help recharge tired eyes.

- Alleviates oxidative stress in the eye and symptoms of Computer Vision Syndrome.

- Helps reduce eye fatigue and strains.

- Has a unique chemical structure that fully spans cell membranes for ultimate protection.

- Does not disrupt cell membrane structure.

- Does not convert to Vitamin A.

- Contains anti-inflammatory properties.

- Crosses the blood retinal barrier and the blood-brain barrier.

- Improves capillary blood flow.

- Reduces inflammation of the capillary muscle.

- Improves accommodation responsiveness, range, and resilience.

- Has over 60 human clinical trials for a variety of health benefits, including eye health.

- Studies have shown that Natural Astaxanthin may provide significant protection to the mitochondria, thus preventing muscle damage.

- Over 50 human studies, including 23 double-blind, placebo-controlled trials, with more than 1,400 participants undergoing treatments lasting from 2 weeks to 6 months, have been conducted.

Bilberry extracts (Vaccinium myrtillus) are extracted from a fruitcalled ‘Vaccinium Myrtillus,’ grown in the north of central Europe.

This humble berry packs a potent compound of plant pigments calledanthocyanins shown to promote healthy tear secretion, improve vision, increase retinal sensitivity (including night vision), and may help prevent common eye issues as we mature. More than 50 positive studies, including at least 25 controlled or double-blind studies, have validated the efficacy of vascular health in Bluerex Vision‘s bilberry extract.

Our Vitamin E (d-alpha-tocopherol) is a select type of natural and pure Vitamin E shown to help neutralize oxidative damage that leads to age-related vision problems and help subjects with moderate age-related macular degeneration. The nutrients reduced the risk of developing advanced age-related macular degeneration by 25% for subjects who already demonstrated early signs of macular degeneration.

Our Vitamin E in natural form is retained better and for a longer time in the body when compared to its synthetic counterpart. As a result, Natural Vitamin E (d-alpha-tocopherol) is more efficiently used by the body than its synthetic counterpart and has higher bioavailability.

Docosahexaenoic acid, or DHA, is a polyunsaturated omega-3 fatty acid(PUFA) found throughout the body. It is a primary structural fat found in the brain and eye, accounting for up to 97% of the total omega-3 fats in the brain and up to 93% of the omega-3 fats in the retina. It is also a key component ofthe heart. Numerous research studies confirm that everyone, from infants to adults to the elderly, can benefit from a regular intake of dietary DHA. DHAaccounts for up to 97% of the total omega-3 fats in the brain. Our DHA is anutritional oil derived from the marine alga, Schizochytrium sp., a rich source of Omega-3 docosahexaenoic acid (DHA) with rosemary extract (flavoring). It is vegetarian and provides essential brain, eye, and heart health benefits and contributes to the maintenance of normal vision.

Our Docosahexaenoic Acid is sourced in the United States.

Take two (2) soft gels daily: 1 in the morning and 1 in the evening, with food, or as directed by your healthcare professional.

Yes, Bluerex is a vegan dietary supplement. It is made from plant-based ingredients, including the capsules. This allows everyone to take the supplement regardless of personal or religious dietary restrictions.

Yes. All our key ingredients are exclusively sourced from trusted suppliers. Other brands often obtain their key ingredients from multiple untraceable animal sources and often from third-world countries.

- Multiple clinical studies substantiate all advertised health benefits and claims.

- All clinical trials conducted on our ingredients are randomized, double-blind, placebo-controlled, and published.

- Clinically proven claims represent the highest medical test for any benefit and are rarely used for nutraceutical products.

- The efficacy of our clinically proven ingredients is guaranteed.

- Bluerex Vision undergoes the same rigorous manufacturing and internal regulatory processes as our pharmaceutical drugs.

When ciliary muscle fatigue, they can cause asthenopia or accommodation failure, and poor blood flow struggles to support a metabolically active organ.

High energy blue light can damage our eyes. It is a component of visible light that we are exposed to it without even realizing it. Blue Light is not easily filtered by our eyes, and over exposure can negatively impact vision.

Nearly every source of light—whether natural or artificial—emits harmful blue light. Over the last few years, the increasing use of technology anddigital devices means people are subjecting themselves to higher levels of BlueLight and risking harm to their eyes.

Everyone who is exposed to digital devices. 60% of Americans use digital devices more than 5 hours daily; 75% of Americans use digital devices in the hour before going to sleep; 70% of Americans use 2 or more digital devices at the same time; 75% of those people report experiencing symptoms of ComputerVision Syndrome. Additionally, 33% of children use devices more than 3 hours daily; 87% of millennials use 2 or more devices simultaneously; 37% of millennials use devices more than 9 hours daily.

Yes, it does have short-term effects such as headaches, eye strain, blurred vision, eye fatigue, and dry eye.

Yes, it does have long-term effects such as retinal damage, reduced visual performance, poor glare recovery, and age-related eye conditions.

In today’s world, every human being is taking advantage of technology. Technology is everywhere. We are glued to multiple digital devices; screens, phones, tablets, computers, and television. Studies have shown that over a third of adults spend more than half their day using technology, while others have admitted that their technology usage consumes 10–12 hours of their time per day. Adults aren’t the only ones being affected, as kids are becoming more involved with devices and other forms of technology at home and in the classroom. 50-90% of digital device users suffer Computer Vision Syndrome (CVS) or Digital Eye Strain symptoms.

- 33% report experiencing eye strain

- 23% report experiencing dry eyes

- 22% report experiencing blurred vision

The eyes are naturally at rest with a view distance of 20 feet away, but by using a phone, tablet, or computer, they are generally 18-24 inches away. This causes a prolonged contraction of ciliary muscles, increasing ROS/free radicals and stressing the eyes. Ciliary muscles spasm to adjust to close proximity viewing—the eyes fatigue, resulting in blurred vision and headaches.

Ciliary muscles adjust lens thickness to change the eye’s focal length. Ciliary muscle provides near point of focus, depth perception, positive accommodation speed, and accommodation amplitude.

Ciliary muscles can contract, rounding the lens and allow you to focuson near objects. Additionally, ciliary muscles can relax, flattening the lensand enable you to focus on distant objects.

Accommodation is defined as the ability of the eye to change its focusfrom distant to near objects (and vice versa). A human eye can change focus from distance infinity to 7cm in 350 milliseconds. This dramatic change in focal power occurs as a consequence of reduction in the zonular tension induced by the ciliary muscle. Put simply, the circular ciliary muscles inside the eyes contract to focus on near subjects and relax to focus on distant subjects. During a long computer session, the eyes exert substantial energy to focus on the computer screen; therefore, vision can be temporarily blurred after a long computer session.

We should care because healthier mitochondria result in better nourishment for the organelle that fuels all cell activity in the body. Also,an organism’s longevity is directly correlated to the amount of free radical damage created within the mitochondria. Without your mitochondria producing enough Adenosine Tri-Phosphate (ATP), every activity in your body would cease. ATP is a high-energy molecule that stores the energy we need to do just about everything we do. Our mitochondria produce the energy of life. For this reason, we need to secure more antioxidant protection from our diet to supplement the defenses our body makes.

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